ABSTRACT
The present study aims to assess the level of knowledge of DM among non diabetic people from Ajman and Ras Al Khaimah (UAE) regard to causes, complication, clinical manifestation, management, treatment, drug adherence and control, hypoglycemia associated with diabetic therapy, hypoglycemia management and other aspects related to diabetes. A cross-sectional study was conducted among non diabetic people who were attending GMCH (Gulf Medical College Hospital) community pharmacy in Ajman and RAK hospitals during the period between July and December 2009. A self-administered questionnaire was used as a tool for data collection. The percentage of participants aware of diabetes causes, symptoms, complications, management, drug treatment, drug therapy adherence and diabetes monitoring were 60.4%, 78.7%, 54.8%, 68.9%, 89.8%, 50.6%, and 76.6% respectively. Awareness of hypoglycemic symptoms which can complicate diabetes therapy was only low 23.8%. For the management of hypoglycemia 45.1% of the participants recommended the use of sugar, 23% of them suggested the use of oral medicine and 32% of the participants recommended the use of insulin. The proportions of participants who had correct knowledge of the recommended frequency of follow-up of eye exam, urine test, blood sugar measurement and blood pressure test in diabetic patients were 33.6%, 39.6%, 87.2% and 23.8 respectively. The study showed low awareness of the population about various aspects of diabetes and the least knowledge was noticed on hypoglycemic symptoms, hypoglycemia management and diabetes complications. We recommend education program to improve population knowledge regards diabetes which can create enthusiasm to improve diabetes care and can go a long way in the prevention and management of diabetes in the Gulf region and UAE in particular.
ABSTRACT
Maximum antiinflammatory activity of phytic acid (PA) was seen at an oral dose of 150 mg/kg in the carrageenan induced rat paw edema model. Although PA showed ability to prevent denaturation of proteins, it showed less antiinflammatory activity than ibuprofen. Ability of PA to bring down thermal denaturation of proteins might be a contributing factor in the mechanism of action against inflammation. PA, at all the doses tested, showed significant protection from ulcers induced by ibuprofen, ethanol and cold stress, with a maximum activity at 150 mg/kg. There was a significant increase in gastric tissue malondialdehyde levels in ethanol treated rats but these levels decreased following PA pretreatment. Moreover, pretreatment with PA significantly inhibited various effects of ethanol on gastric mucosa, such as, reduction in the concentration of nonprotein sulfhydryl groups, necrosis, erosions, congestion and hemorrhage. These results suggested that gastro-protective effect of PA could be mediated by its antioxidant activity and cytoprotection of gastric mucosa.